Published Medical Papers

There is a growing body of evidence to support the use of SurgihoneyRO. It has been shown to kill superbugs in the laboratory and heal chronic wounds.

Laboratory tests compared it to other wound care products and clinical studies demonstrated positive outcomes for a variety of acute and chronic wounds.

Most of the published medical papers and posters can be viewed on this website and all are available on request at info@reactiveoxygen.com

Journal of Trauma & Orthopaedics – Debridement Defining Something We Do
8th December 2016

Peer-reviewed article by Wasim Khan & Rhidian Morgan-Jones describing how in the modern management of orthopaedic infection, debridement – removal of damaged tissue from a wound – is paramount. Surgihoney is mentioned as a chemical debridement agent “which works by a local osmolar effect but also produced hydrogen peroxide. Surgihoney also has the potential to…

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Poster – SurgihoneyRO in successful management of Necrotising Fasciitis with multi-drug resistant colonisers
6th October 2016

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Journal of Antimicrobial Chemotherapy – Antimicrobial Stewardship in Wound Care
26th July 2016

Antimicrobial stewardship in wound care: a Position Paper from the British Society for Antimicrobial Chemotherapy and European Wound Management Association Benjamin A. Lipsky; Matthew Dryden; Finn Gottrup; Dilip Nathwani; Ronald Andrew Seaton; Jan Stryja Journal of Antimicrobial Chemotherapy 2016; doi: 10.1093/jac/dkw287 This guidance document for clinicians suggests that applying the principle of antimicrobial stewardship to…

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Poster – Surgihoney as a novel antimicrobial coating in salvage revision total knee arthroplasty
7th July 2016

This poster presentation to 2015 European Bone & Joint Infection Society in Lisbon by Rhodri Llewyn Williams, Wasim Khan,  Amisha Metah and Rhydian Morgan-Jones, Department of Orthopaedic Surgery, University Hospital of Wales, presents first reported use of Surgihoney as a novel, antimicrobial, deep implant coating in the salvage of prosthetic joint infection. Please note this medical use is outside of the indications…

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International Journal of Antimicrobial Agents – The diagnosis and management of skin infections
27th May 2016

International Journal of Antimicrobial Agents. Hot Topics article, on behalf of the International Society of Chemotherapy, features Surgihoney RO, engineered honey producing reactive oxygen species (ROS), as potent antimicrobial. “It is effective in the management of acute and chronic wound infections, in the prevention of surgical wound infections, in reducing and preventing intravascular line site colonisation and…

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Journal of Wound Care – A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds
19th April 2016

Journal of Wound Care – This article reports outcome of use of Surgihoney RO (SHRO) topical wound dressing in a multi-centre, international setting. It concluded: “SHRO was well tolerated and shows great promise as an effective, topical antimicrobial in the healing of challenging wounds.”

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Journal of Wound Care – In vitro activity of an engineered honey, medical-grade honeys and antimicrobial wound dressings against biofilm-producing clinical bacterial isolates
13th February 2016

Journal of Wound Care: – New research by the National Institute for Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre shows Surgihoney is highly effective at tackling bacterial biofilm found in long-term wounds. Surgihoney prevented biofilm formation for all 16 bacteria tested, both Gram-positive and Gram-negative, including multi-drug resistant strains such as MRSA, E.Coli and Pseudomonas aeruginosa.  The research concluded:…

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International Wound Journal – Reactive Oxygen Species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for the implementation of the healing process
4th January 2016

International Wound Journal. This article presents a review of the evidence supporting the critical role of ROS in wound healing and infection control at the wound site. It highlights Surgihoney as a promising ROS-dependent antibacterial agent for treating and preventing wound infections. Dunnill C, Patton T, Brennan J, et al. Reactive oxygen species (ROS) and…

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Poster – The in vitro antibacterial activity of engineered honey (Surgihoney) against important biofilm-forming burn wound pathogens
25th April 2015

Poster presentation to ECCMID conference 2015. The authors concluded “Our experiments show Surgihoney can prevent biofilm formation and reduce the seeding of pre-formed biofilms. Surgihoney is therefore a promising topical antimicrobial agent with potent anti-biofilming activity against key Gram-negative and Gram-positive pathogens of wound burns”

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BMC Research Notes – The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide
3rd February 2015

BMC Research Notes – First evidence showing potent antimicrobial activity of Surgihoney is largely due to ROS hydrogen peroxide activity and it can be scaled up. It offers a dressing that is “effective, non-toxic and easy to administer.”

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Poster – The in vitro antibacterial activity of engineered honey (Surgihoney) against important biofilm-forming burn wound pathogens
26th November 2014

Poster presentation to Federation of Infection Societies (FIS) 2014 conference. In vitro research concluding Surgihoney is “a promising, topical antimicrobial agent with potent antibiofilm activity.”

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Journal of Hospital Infection – Infection prevention in wounds with Surgihoney
6th August 2014

Journal of Hospital Infection – early clinical evidence showing Surgihoney can clear multi-drug resistant bacteria in wounds. The use of antibiotics was not necessary. The three case studies include patients with Escherichia coli (CPE), MRSA and Pseudomonas aeruginosa.

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Journal of Wound Care – The use of Surgihoney to prevent or eradicate bacterial colonisation in dressing oncology long vascular lines
3rd June 2014

Journal of Wound Care. Case report on female breast cancer patient receiving chemotherapy via Hickman line. Swab showed Carbapenemase-producing Esch.coli (CPE) on oozing line site exit. Surgihoney applied to line site dressing and screening after two weeks showed eradication of multi-drug resistant bacteria, demonstrating infection prevention potential.

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Journal of Global Antimicrobial Resistance – Engineered honey: in vitro antimicrobial activity of a novel topical wound care treatment
1st May 2014

Journal of Global Antimicrobial Resistance. In vitro research showing Surgihoney, a new bioengineered honey, is highly active against a wide range of Gram-positive and Gram-negative bacteria, including multi-drug resistant pathogens. It is a more potent antimicrobial agent than other honeys tested, including Medihoney. Dryden M. Lockyer G. Kordo S. Cooke J. Engineered honey: in vitro…

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Current Opinion in Infectious Diseases – When antibiotics can be avoided in skin inflammation and bacterial colonization
28th February 2014

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