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Terms of Use

STANDARD TERMS AND CONDITIONS

FOR SALE OF GOODS

OF H&R HEALTHCARE LIMITED

1              DEFINITIONS

In this document the following words shall have the following meanings:

1.1           “Buyer” means the organisation or person who buys Goods from the Seller;

1.2           “Goods” means the articles to be supplied to the Buyer by the Seller;

1.3           “List Price” means the list of prices of the Goods maintained by the Seller as amended from time to time;

1.4           “Seller” means H&R Healthcare Ltd, whose registered address is at Pembroke House, 15 Pembroke Road, Clifton, Bristol, Gloucestershire, BS8 3BA

2              GENERAL

2.1           These Terms and Conditions shall apply to all contracts for the sale of Goods by the Seller to the Buyer to the exclusion of all other terms and conditions referred to, offered or relied on by the Buyer whether in negotiation or at any stage in the dealings between the parties, including any standard or printed terms tendered by the Buyer, unless the Buyer specifically states in writing, separately from such terms, that it wishes such terms to apply and this has been acknowledged by the Seller in writing.

2.2           Any variation to these Terms and Conditions (including any special terms and conditions agreed between the parties) shall be inapplicable unless agreed in writing by the Seller.

3              PRICE AND PAYMENT

3.1           The price shall be that in the Seller’s current List Price, or such other price as the parties may agree in writing. The price is exclusive of VAT or any other applicable costs. Standard carriage shall be paid for by the Seller subject to a minimum order value of £100excl. VAT. Where the value of any delivery is less than this figure a packing/delivery charge of £12 shall be levied (prescription items supplied direct to pharmacies are exempt from this charge)

3.2           Overnight/special deliveries will be charged at actual cost of the delivery where specifically requested by the Buyer.

3.3           Payment of the price and VAT and any other applicable costs shall be due within 30 days of the Shipping Date of the Goods supplied by the Seller.

3.4           The Buyer shall not be entitled to withhold payment either wholly or in part once the same has become due except where expressly agreed with the Seller.

3.4           The Seller shall be entitled to charge interest on overdue invoices from the date when payment becomes due from day to day until the date of payment at a rate of 2% per annum above the base rate of the Bank of England.

3.5           If payment of the price or any part thereof is not made by the due date, the Seller shall be entitled to:

3.5.1        require payment in advance of delivery in relation to any Goods not previously delivered;

3.5.2        refuse to make delivery of any undelivered Goods whether ordered under the contract or not and without incurring any liability whatever to the Buyer for non-delivery or any delay in delivery;

3.5.3        terminate the contract.

3.6           No notice of cancellation of an order shall be valid unless agreed in writing by an authorised representative of the seller.

4              DESCRIPTION

Any description given or applied to the Goods is given by way of identification only and the use of such description shall not constitute a sale by description.  For the avoidance of doubt, the Buyer hereby affirms that it does not in any way rely on any description when entering into the contract.

5              SAMPLE

Where a sample of the Goods is shown to and inspected by the Buyer, the parties hereto accept that such a sample is so shown and inspected for the sole purpose of enabling the Buyer to judge for itself the quality of the bulk, and not so as to constitute a sale by sample.

6              DELIVERY

6.1           Unless otherwise agreed in writing, delivery of the Goods shall take place at the address specified by the Buyer on the date specified by the Seller.  The Buyer shall make all arrangements necessary to take delivery of the Goods whenever they are tendered for delivery.

6.2           The date of delivery specified by the Seller is an estimate only.  Time for delivery shall not be of the essence of the contract.

6.3           The Buyer shall be entitled to replacement Goods where the Goods have been damaged during transportation.  The Buyer must notify the Seller of the damage within 24 hours of delivery.

6.4           Claims for non-delivery must be notified to the Seller within 24 hours of receipt of invoice, failing which the Seller shall be under no liability for non-delivery.

6.5           Shortages or surpluses should be reported to the Seller within 24 hours of receipt of delivery.

6.6           Goods ordered in error can be returned for credit in a saleable condition and will be subject to a 20% re-stocking fee.

7              RISK

Risk in the Goods shall pass to the Buyer at the moment the Goods are tendered for delivery at the delivery point specified in the order.  Where the Buyer chooses to collect the Goods itself, risk will pass when the Goods are entrusted to it.

8              TITLE

Title in the Goods shall not pass to the Buyer until the Seller has been paid in full for the Good

9              WARRANTY

9.1           Where the Goods have been manufactured by the Seller and are found to be defective, the Seller shall replace defective Goods free of charge within 30 days from the date of delivery, subject to the following conditions:

9.1.1        the Buyer notifying the Seller in writing immediately upon the defect becoming apparent;

9.1.2        the defect being due to the faulty design, materials or workmanship of the Seller.

9.2           Any Goods to be repaired or replaced shall be returned to the Seller, if so requested by the Seller.

9.3           Where the Goods have been manufactured and supplied to the Seller by a third party, any warranty granted to the Seller in respect of the Goods shall be passed on to the Buyer.

9.4           The Seller shall be entitled in its absolute discretion to refund the price of the defective Goods in the event that such price has already been paid.

9.5           The remedies contained in this Clause are without prejudice to the other Terms and Conditions herein, including, but without limitation, Clauses 10 and 11 below.

10            LIABILITY

10.1         No liability of any nature shall be incurred or accepted by the Seller in respect of any representation made by the Seller, or on its behalf, to the Buyer, or to any party acting on its behalf, prior to the making of this contract where such representations were made or given in relation to:

10.1.1      the correspondence of the Goods with any description;

10.1.2      the quality of the Goods; or

10.1.3      the fitness of the Goods for any purpose whatsoever.

10.2         No liability of any nature shall be accepted by the Seller to the Buyer in respect of any express term of this contract where such term relates in any way to:

10.2.1      the correspondence of the Goods with any description;

10.2.2      the quality of the Goods; or

10.2.3      the fitness of the Goods for any purpose whatsoever.

10.3         All implied terms, conditions or warranties as to the correspondence of the Goods to any description or the satisfactory quality of the Goods or the fitness of the Goods for any purpose whatsoever (whether made known to the Seller or not) are hereby excluded from the contract.

11            LIMITATION OF LIABILITY

11.1         Where any court or arbitrator determines that any part of Clause 10 above is, for whatever reason, unenforceable, the Seller shall be liable for all loss or damage suffered by the Buyer but in an amount not exceeding the contract price.

11.2         Nothing contained in these Terms and Conditions shall be construed so as to limit or exclude the liability of the Seller for death or personal injury as a result of the Seller’s negligence or that of its employees or agents.

12            FORCE MAJEURE

The Seller shall not be liable for any delay or failure to perform any of its obligations if the delay or failure results from events or circumstances outside its reasonable control, including but not limited to acts of God, strikes, lock outs, accidents, war, fire, breakdown of plant or machinery or shortage or unavailability of raw materials from a natural source of supply, and the Seller shall be entitled to a reasonable extension of its obligations. If the delay persists for such time as the Seller considers unreasonable, it may, without liability on its part, terminate the contract.

14            RELATIONSHIP OF PARTIES

Nothing contained in these Terms and Conditions shall be construed as establishing or implying any partnership or joint venture between the parties and nothing in these Terms and Conditions shall be deemed to construe either of the parties as the agent of the other.

15            ASSIGNMENT AND SUB-CONTRACTING

The contract between the Buyer and Seller for the sale of Goods shall not be assigned or transferred, nor the performance of any obligation sub-contracted, in either case by the Buyer, without the prior written consent of the Seller.

16            WAIVER

The failure by either party to enforce at any time or for any period any one or more of the Terms and Conditions herein shall not be a waiver of them or of the right at any time subsequently to enforce all Terms and Conditions of this Agreement.

17            SEVERABILITY

If any term or provision of these Terms and Conditions is held invalid, illegal or unenforceable for any reason by any court of competent jurisdiction such provision shall be severed and the remainder of the provisions hereof shall continue in full force and effect as if these Terms and Conditions had been agreed with the invalid, illegal or unenforceable provision eliminated.

18            GOVERNING LAW AND JURISDICTION

This Agreement shall be governed by and construed in accordance with the law of England and the parties hereby submit to the exclusive jurisdiction of the English courts.

 

H&R HEALTHCARE LIMITED SEPTEMBER 2006


Clinical Evidence

Reactive Oxygen® Made Easy

Reactive Oxygen® Made Easy

Dryden, M. and Stephens, C., Wounds UK, 2018, 14 (5)

A multi-centre clinical evaluation of SurgihoneyRO™ in 114 wounds

Dryden, M., Dickinson, Brooks, J., A., Hudgell, L., Saeed, K. and Cutting, K.F., Journal of Wound Care, 2016, 25 (3)

A multi-centre clinical evaluation of SurgihoneyRO™ in 114 wounds

Using antimicrobial SurgihoneyRO™ to prevent caesarean wound infection

Dryden, M., Goddard, C., Madadi, A., et al., British Journal of Midwifery, 2014, 22 (1)

Using antimicrobial SurgihoneyRO™ to prevent caesarean wound infection

A topical antimicrobial wound gel to treat multi-drug resistant pathogens in wound care

Thomas, H., Davies, L. and Westgate, S.J., Poster, Perfectus biomed, 2018

A topical antimicrobial wound gel to treat multi-drug resistant pathogens in wound care
Treatment of World Health Organisation priority pathogens using an antimicrobial wound gel

Treatment of World Health Organisation priority pathogens using an antimicrobial wound gel

Thomas, H., Davies, L. and Westgate, S.J., Poster, Perfectus biomed, 2018

Bioengineered honey: in vitro antimicrobial activity of a novel topical wound care treatment

Dryden, M., Journal of Global Antimicrobial Resistance & Journal of Antimicrobial Chemotherapy, 2014

Bioengineered honey: in vitro antimicrobial activity of a novel topical wound care treatment

How to apply

SurgihoneyRO™ is applied directly to the wound bed or surgical incision site

To ensure optimum results please follow the following guidelines:

  • Cleanse the wound as per local guidelines
  • Apply 2mm thickness directly to the wound bed. Alternatively, SurgihoneyRO™ can be applied to an inert wound contact or secondary dressing then placed on the wound bed
  • Select an appropriate secondary dressing for exudate level and to maintain moist wound healing environment
  • A tube of SurgihoneyRO™ may be used on a single patient, multiple times, for up to 28 days

It is recommended that SurgihoneyRO™ is applied every 72 hours (3 days) and more frequently in critical wound infections to maximise effect.

  • For critically infected wounds, it is recommended that SurgihoneyRO™ is applied daily then reduce to alternate days, then to every 3 days over the first 2 weeks (subject to individual clinical scenario). If there is no improvement in the wound condition and microbial status use should be reviewed
  • For surgical incision sites, it is recommended to apply SurgihoneyRO™ once immediately after closure to assist healing and as a secondary infection prevention measure

SurgihoneyRO™ may be used under compression bandaging for up to 7 days however potency will decrease after day 3.

With a low therapeutic dose of H202 there are no contraindications associated with long term use and it is non-toxic to healthy tissue. It may be used on children.

Indications for use

SurgihoneyRO™ is indicated for infected, chronic and acute wounds through to wound healing

Chronic wounds including:-

  • Diabetic foot ulcers
  • Pressure ulcers
  • Leg ulcers

Infected wounds

Acute wounds including:-

  • Surgical wounds
  • Traumatic wounds, cuts and abrasions
  • Burns
  • Donor and recipient sites

SurgihoneyRO™ is a safe and effective multi-action product without the drawbacks of other antimicrobial wound dressings. The bioengineering ensures a consistent level of therapeutically active Reactive Oxygen® which aids the antimicrobial activity for up to 3 days.

Why is it different?

When SurgihoneyRO™ comes into contact with moisture, Reactive Oxygen® is instantly released and sustained for over 72 hours1

Medical-grade honey is an established topical treatment for wounds and burns due to its antimicrobial and wound healing promotion activity. It provides rapid autolytic debridement, reduces odour and decreases wound-related pain and bio-burden2. Honey works in a different way to antibiotics – it is hypersomolar, restricting the availability of water to bacteria and dehydrating bacteria by osmosis.

Natural honeys vary hugely in their antimicrobial properties and there is little consistency in antimicrobial effects because there can be no control over nectar source, sugar content and other contaminants in entirely natural products. Many medicinal honeys are based on Manuka honey, which is one of the more antimicrobial natural honeys.

Different mechanisms of action have been suggested for the antimicrobial effects of honey, but the main ones are the high-sugar concentration, H2O2, the 1,2-dicarbonyl compound methylglyoxal (MGO), the cationic antimicrobial peptide bee defensin-1 and the low pH3. Some patients may experience momentary stinging or a drawing sensation when using honey therapies due to its autolytic debriding properties and the drawing of fluids by osmosis away from the wound4.

SurgihoneyRO™ has all the natural healing-inducing, desloughing and tissue regenerative properties of the honey carrier, but it has been bioengineered to deliver precisely controlled level of Reactive Oxygen®.

SurgihoneyROTM is a fast acting, effective antimicrobial.

The speed of cidal activity is shown by the time-kill curves to be extremely rapid, by 30 mins the bacteria had fallen 1,000-fold. All bacteria were killed within 48 hours4.

References

Reactive Oxygen®

SurgihoneyRO™ is the first published, antimicrobial wound dressing that has been tested against the 12 priority MDR bacterial strains, and has been shown to be effective against almost all these organisms1

The term reactive oxygen species (ROS) describes highly reactive molecules containing reduced oxygen or oxygen atoms with extra electrons. Members of the ROS family include superoxide anion O2, peroxide O22, hydrogen peroxide H2O2.

ROS are naturally occurring in the body. Basal ROS levels maintain normal cell functioning and homeostasis2, while increased amounts induce a cell-mediated antimicrobial defence response3.

ROS are part of the innate immune response, and play a critical role in wound healing and infection control at the wound site4. They are released within minutes of epithelial injury, signalling rapid recruitment of leukocytes5. ROS directly damage microbes that invade tissues6. In wound healing, ROS are secondary messengers to many immunocytes and non-lymphoid cells, and regulate angiogenesis, haemostasis and tissue repair7.

Reactive Oxygen® is the antimicrobial mechanism for SurgihoneyRO™. In contact with moisture, SurgihoneyRO™ releases Reactive Oxygen®.

In vitro studies have shown that Reactive Oxygen® at close to naturally occurring levels:

  • Stimulates proliferation of human fibroblasts and vascular endothelial cells5,13
  • Stimulates angiogenesis via vascular endothelial growth factor (VEGF) signalling14
  • Promotes keratinocyte cell migration and proliferation15

A controlled and sustained level of H2O2 that is non-harmful and non-toxic to surrounding tissue, is a therapeutic opportunity for wound care. SurgihoneyRO™ does this through the release of Reactive Oxygen®. To find out more on the technology of SurgihoneyRO™ and Reactive Oxygen®, read the Reactive Oxygen Made Easy.

Research
Scientists from the National Institute for Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre, the research arm of the NHS, demonstrated SurgihoneyRO™ is highly effective at tackling a wide variety of bacterial biofilm found in chronic wounds in vitro.

“Given the threat posed by antimicrobial resistance and the ever-increasing need to find new solutions to treat infections, SurgihoneyRO™ has real potential as a new wound care agent to kill bacteria and disrupt biofilm.” – Fenella Halstead, Clinical scientist, National Institute for Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre.

SurgihoneyRO™ has been successfully used for infection prevention, eradication of MDR bacterial strains and prevention of surgical site infections and intravascular line care in vivo15,16,17.

The Reactive Oxygen® released by SurgihoneyRO™ is a broad-spectrum antimicrobial against wound-relevant MDR bacterial strains and has been shown to prevent and disrupt and eradicate mature biofilm.

SurgihoneyRO™ presents one option against the growing global issue of antimicrobial resistance.

 

References

What is SurgihoneyRO™?

SurgihoneyRO™ is a cutting-edge technology, an antimicrobial wound gel utilising bioengineered honey to deliver Reactive Oxygen® (RO™)

SurgihoneyRO™ provides enhanced healing and a powerful antimicrobial action to reduce the microbial load thus removing the barriers to wound healing. Unlike other medical grade honeys, SurgihoneyRO™ has been bioengineered to enhance and precisely control its antimicrobial potency.

  • Kills a wide range of bacteria in vitro1,2,3
  • Prevents biofilm in vitro1
  • Fast acting antimicrobial action2
  • Substantially eradicates mature biofilm in vitro4,5
  • Effective against multi drug-resistant microorganisms commonly found in chronic wounds6
  • Effective debridement
  • Assists the natural wound healing environment and promotes new tissue growth

SurgihoneyRO™ is the only published, proven antimicrobial wound dressing tested against the WHO priority pathogens6.

References